Ruth Lehmann reflects on advancements in developmental biology over 25 years, highlighting the unpredictable nature of scientific discovery. From dissecting cell migration to understanding morphogenesis and genetic pathways, she emphasizes the importance of curiosity-driven research. Advances in single-cell sequencing and genetic manipulation tools like CRISPR have revolutionized studies. However, despite progress, challenges remain in fully understanding life’s principles. Ruth advocates for robust funding for basic science, acknowledging its pivotal role in healthcare breakthroughs. She warns against overlooking foundational research, stressing the importance of intellectual freedom in scientific exploration and societal progress. Ultimately, Ruth Lehmann calls for a balanced approach to scientific funding to maximize discovery potential.